Kybella® is the first and only FDA-approved injectable treatment that permanently destroys fat cells beneath the chin, addressing the common concern of submental fullness—or the so-called “double chin.” Derived from deoxycholic acid, a bile acid naturally produced in the body to help absorb dietary fats, Kybella® works by disrupting the membranes of adipocytes (fat cells) in the targeted area. Once these membranes rupture, the body’s immune system naturally clears the cellular debris over time, leading to a slimmer, more defined jawline without the scarring, anesthesia or downtime associated with surgical procedures.
What is Kybella®?
Kybella® consists of a synthetic form of deoxycholic acid formulated specifically for injection. When deposited into the preplatysmal and submental fat compartments, it triggers a controlled, localized inflammatory response that breaks down fat cell membranes. Unlike liposuction or fat-freezing technologies, Kybella® relies on a series of precise injections rather than incisions, energy devices or general anesthesia. Because the fat cells are permanently eliminated, they cannot return—provided patients maintain a stable weight after treatment.
How Kybella® Works
During each session, a grid pattern is marked to ensure that small aliquots of Kybella® are evenly delivered across the treatment area, while avoiding sensitive structures such as the marginal mandibular nerve. After topical anesthesia or ice is applied for comfort, a fine-gauge needle injects the solution into the subcutaneous fat layer. Over the next few days, the deoxycholic acid emulsifies fat cell walls, initiating a cleanup by macrophages. Visible reduction in fat volume generally becomes apparent four to six weeks after each treatment, with optimal contouring achieved after a custom series of two to four sessions spaced at least one month apart.
Ideal Candidates and Treatment Areas
The primary indication for Kybella® is moderate to severe submental fat in adults with good overall health and stable body weight. Ideal candidates understand that Kybella® refines only localized fat deposits and does not tighten loose or sagging skin. Patients with skin laxity beneath the chin may require adjunctive tightening treatments—such as radiofrequency microneedling or ultrasound skin tightening—to achieve optimal firmness. Off-label, some injectors also use Kybella® to target small fat pockets along the jawline, beneath the jowls or even on the upper arms and abdomen, though these applications should only be performed by experienced, board-certified providers.
The Kybella® Procedure
On the day of treatment, the provider maps out the fat compartments using anatomical landmarks, marking injection points approximately one centimeter apart. After numbing the area, multiple microinjections deliver precise doses of Kybella®—no more than 0.2 milliliters per site—across the submental region. The process takes under thirty minutes, after which patients can often return to normal activities with minimal restriction. There are no sutures or dressings required, though some choose to wear a loose, supportive chin strap for added comfort during the first night.
Recovery and Aftercare
Swelling at the treatment site is expected and often peaks two days post-injection, then gradually subsides over one to two weeks. Mild redness, firmness and bruising are common but transient. Cold compresses and over-the-counter pain relievers help manage discomfort. Patients are advised to sleep with their head elevated and avoid vigorous neck movements for 48 hours. Because the inflammatory process continues for weeks after each session, contour refinement unfolds gradually, with most individuals seeing measurable improvement four to six weeks after treatment.
Safety Profile and Potential Side Effects
When administered by qualified injectors, Kybella® has an excellent safety record. The most commonly reported reactions include swelling, bruising, numbness, redness and firmness at injection sites. Rarely, temporary marginal mandibular nerve injury can cause mild weakness of the lower lip, which typically resolves within one to two months. Choosing an experienced, board-certified plastic surgeon, dermatologist or facial plastic surgeon minimizes these risks through meticulous technique and precise anatomical knowledge.
Cost and Investment
The total investment in Kybella® varies based on individual anatomy, the amount of submental fat and the number of sessions required. In the United States, a full series of two to four treatments typically ranges from $1,200 to $1,800. In continental Europe, comparable treatment packages start around €900 and can go up to €1,500, depending on local market factors and provider expertise. In the United Kingdom, most patients pay between £800 and £1,300 for an equivalent series. MeTime-affiliated providers furnish transparent, all-inclusive quotes covering consultations, injection fees and follow-up care. Financing plans and discounted bundled sessions help patients integrate Kybella® into their budgets without compromising on quality.
Combining Kybella® with Complementary Treatments
For patients whose submental fat reduction reveals mild skin laxity, combining Kybella® with noninvasive tightening modalities enhances overall outcomes. Radiofrequency microneedling stimulates collagen remodeling for firmer skin, while high-intensity focused ultrasound (HIFU) targets deeper tissue layers for lift and tone. Injectable hyaluronic acid fillers can then be used to sculpt jaw angles or augment a receding chin, creating balanced facial proportions. A staged, multimodal regimen—carefully sequenced and tailored to each patient—ensures seamless, natural-looking results.
Long-Term Results and Maintenance
Because Kybella® permanently destroys fat cells, long-term durability is excellent when patients maintain a stable weight. Unlike temporary fillers, there is no need for repeated injections once the desired contour is achieved. However, modest weight gain can lead to fat accumulation in untreated areas. Annual check-ins allow providers to evaluate jawline definition and discuss any touch-up options—whether a single Kybella® booster or a noninvasive skin-tightening session—to preserve the sculpted appearance.
Selecting a Qualified Provider
Optimal safety and aesthetic precision hinge on choosing a provider with extensive experience in injectable fat reduction. Prospective patients should confirm board certification in plastic surgery, dermatology or facial plastic surgery, review before-and-after galleries, and read patient testimonials. MeTime’s directory simplifies this process by aggregating verified provider profiles, procedural volumes and patient satisfaction ratings in one secure platform. During consultation, ask about the injector’s complication management strategies, anatomical training, and approach to blending Kybella® with complementary treatments.
Frequently Asked Questions
Does Kybella® really work?
Clinical trials show that Kybella® produces significant, permanent submental fat reduction in most patients after a series of injections. Visible improvements often appear four to six weeks after each session.
Is Kybella® permanent?
Yes. The fat cells destroyed by Kybella® do not regenerate. Long-term maintenance depends on stable body weight and healthy lifestyle habits.
What exactly does Kybella® do?
Kybella® emulsifies the membranes of fat cells in the submental area. Your body’s lymphatic and immune systems then clear the cellular debris, gradually thinning the fat layer and improving jawline definition.
How long does Kybella® last?
Final results become apparent about six weeks after your last treatment. Because the targeted fat cells are permanently eliminated, results can last indefinitely with proper weight management.
What is the downside of Kybella®?
The main considerations are temporary swelling, bruising, firmness and the rare risk of marginal mandibular nerve irritation. These side effects are generally mild and resolve with time. Careful injection technique by a qualified professional minimizes these risks.
By partnering with a MeTime-verified provider, you can explore whether Kybella® fits your aesthetic goals, combining expert care with a proven, science-backed approach to non-surgical fat reduction.